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Student research project

Supervisor(s): Professor Andrew Murphy and Dr Graeme Lancaster

Identify ways to manipulate specific lipids to alter cell function in disease.

Project summary

Over the past few years we have generated a new and exciting data set profiling the lipid compositions (lipidome) of 16 different human immune cells and the major mouse immune cell equivalents. This revealed striking diversity between various immune cells, particularly between the innate and adaptive immune system.

We are now exploring two overall questions:

  1. Do specific lipids drive immune cell function?
  2. How do the lipidomes of immune cells form as they develop from stem cells.

The specific project can be focused on either of the two questions above.

This project will determine the lipidomes of haematopoietic stem cells and how they change as these cells mature down specific lineages to form mature immune cells. Given we have identified a very unique signature in blood neutrophils (i.e. an enrichment in ether lipids), this project will first explore what happens when we delete an enzyme called glyceronephosphate O-acyltransferase (GNPAT — rate limiting enzyme for the production of ether lipids) specifically in stem cells and explore the neutrophil maturation pathway in the bone marrow and blood. We will also explore some functional properties of neutrophils such as inflammatory signalling in response to bacterial stimuli and phagocytosis. These experiments will be conducted in mice using flow cytometry to quantify cell population and examine the functional readouts.

This project is suitable for a PhD or Honours student and will expose if specific lipids are critical to the development of immune cells.

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