Leaders: Professor Andrew Murphy and Dr Graeme Lancaster
This project involves manipulating human and mouse immune cells in culture. Techniques to explore this question will be cell death assays via flow cytometry and assessment of lipid peroxidation by mass spectrometry. Mouse models will also be used to test this hypothesis in vivo and depending on the applicant (hons/PhD) will use mouse models to genetically modify the lipid composition or ferroptotic pathway of specific immune cells.