Ms Malancha Karmakar
BSc(Hons) | MSc, University of Calcutta, India
After completion of my master’s degree I worked in industry as a research scientist and was part of a Wellcome Trust funded project, where I led the team responsible for mapping the biochemistry and mechanisms of action of 18 known anti-tuberculosis drugs. This in-silico platform was used to study, design and optimise multi-drug combination therapies, which were validated in vitro and in vivo in partnership with AstraZeneca India R&D.
After working for five years in the industry, I moved on to pursue PhD at the University of Melbourne. My current research focusses on building in-silico tools to identify novel mutations in drugs used for treating tuberculosis. The tools we build can help in selecting appropriate and optimal therapies thereby tailoring medical decisions, interventions and practices based on individual patient. Next, I would like to explore how these structural changes alter the fitness and transmission dynamics, influencing the likelihood of resistance spreading using mathematical models.