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Atherothrombosis and Vascular Biology

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Laboratory head

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Latest Achievements

Kempson Maddox Plenary Lecture, Cardiac Society of Australia and New Zealand (2020)

RT Hall Prize for outstanding achievements in cardiovascular research (2014)

Ross Hohnen Award for the best research application, National Heart Foundation (2012)

World Congress of Cardiology Fellowship Award, National Heart Foundation of Australia (2005)

Schwarz-Monheim-Prize of the German Society of Angiology (2000)

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Professor Karlheinz Peter NHMRC L3 Investigator
Developing advanced biotechnological tools for molecular imaging and innovative therapy of atherosclerosis, thrombosis and inflammation.

Staff

Students

Dr Justin Cole Ms Habiba Danish Dr Nalin Dayawansa Ms Najma Fithri Ms Samantha Loong Ms Zhengyuan Liu Dr Jath Palasubramaniam Ms Runali Patil Ms Shania Anggita Prijaya Mr Abhishek Roy Ms Julia Skoraczynski Dr Hannah Stevens Mr Chaya Wickramarathne Dr Abbey Willcox Dr Wen-Kai Wong

Consulting scientist

Professor Geoff Pietersz

 

About the Atherothrombosis and Vascular Biology laboratory

The Atherothrombosis and Vascular Biology laboratory pursues a broad range of projects that have a common focus on improving diagnosis and therapy of thrombotic and inflammatory diseases such as myocardial infarction and atherosclerosis. A range of biotechnological methods is used, including recombinant protein design/production, generation of functionalised nanoparticles/liposomes/microbubbles, various omics technologies (single-cell RNA sequencing, proteomics, lipidomics), various immunological technologies, flow cytometry, flow chamber, microfluidics, intravital microscopy, ultrasound, MRI, PET, various fluorescence imaging systems and various animal models of thrombosis, atherosclerosis (including a unique mouse model of plaque instability) and inflammation. Most recently we have extended our research into the development of mRNA therapeutics. All of these projects have a strong translational orientation, which is facilitated by several laboratory members (physicians/cardiologists/haematologists) treating patients with cardiovascular and haematological diseases as well as cancer. Several of our research projects resulted in patents and the establishment of start-up companies (e.g. Nirtek).

Work in the laboratory is particularly attractive for students and postdoctoral researchers interested in the development of advanced biotechnological tools for molecular imaging and novel therapeutics (e.g. nanoparticles, anti-inflammatory drugs and mRNA therapeutics for plaque stabilisation). The translational direction of the laboratory and the inclusion of patients in studies is highly attractive for physician scientists.

Research focus

  • Molecular imaging of thrombosis and inflammation using MRI, PET, ultrasound, FLECT, and IVIS.
  • Novel recombinant therapeutics for thrombotic and inflammatory diseases.
  • Microfluidic flow chambers.
  • Intravital microscopy.
  • Flow cytometry.
  • Animal models of thrombosis and inflammation.
  • Production of recombinant proteins for diagnosis and therapy.
  • Diagnosis and treatment of patients with coronary artery disease and myocardial infarction.
  • Single-cell RNA sequencing.
  • mRNA therapeutics for cardiovascular diseases.

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With the rising number of Australians affected by diabetes, heart disease and stroke, the need for research is more critical than ever.

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