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Systems Genomics

Leveraging large-scale, systems-level data to extract biological and clinical insights.

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Latest Achievements

NHMRC Career Development Fellow (2014)

National Heart Foundation Future Leader Fellow (2014)

NHMRC Early Career Awardee — Science at the Shine Dome, Australian Academy of Science (2010)

NHMRC Peter Doherty Fellow (2010)

Gates Research Scholar, University of Washington (2002–2004)

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Associate Professor Michael Inouye Laboratory Head
We aim to alleviate the burden of disease using our interdisciplinary strengths in statistics, computation and bioscience.

 

About the Systems Genomics Laboratory

In the last decade, technological advances have driven the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels previously unimaginable, allowing us to study their interactions and relationships to health and disease in an unbiased, systems-level manner.

A corollary of this transformation is that sophisticated quantitative models can now be used to tease out underlying biological insights and pathogeneses of molecular systems. In our view, an 'organism' can be thought of as a system whose components are derived from its genome(s) and which interacts with each other and the environment in a spatial and temporal manner.  We think of these components (e.g. RNAs, proteins, mobilised DNA) as operating as part of networks with the other elements (e.g. metabolites, sunlight, microorganisms). We therefore apply and develop concepts in graph theory, bioinformatics, epidemiology and biostatistics to understand how networks interact and what role they play in human diseases and traits.

Vision

Lead a world-class systems genomics research program focused on leveraging the latest genomic/biomolecular technologies and analytical techniques to alleviate the burden of diseases with immune and inflammatory aetiologies.

Our lab has a long track record of research at the interface of genomics, computer science and statistics. Overall, our aims are to utilise analytical tools to uncover insights into pathogenesis that change clinical practice; build local capacity and link it to international collaborative networks; and champion open and rapid scientific publishing.

Research focus

  • Genomic prediction of common human diseases.
  • Multi-omics analysis to identify and characterise new biomarkers.
  • Development of new statistical/computational approaches to high-dimensional data.

We're a young and dynamic lab who are always looking for talented, inter-disciplinary, and highly motivated postdocs or students. If you're interested in joining, please send us an email with your CV.

 

Support us

With the rising number of Australians affected by diabetes, heart disease and stroke, the need for research is more critical than ever.

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