During my Master’s project (at IIT, India), I explored the intricate mechanism of protein misfolding and protein aggregation, which are implicated in neurodegenerative disease and systemic amyloidosis. Given my background in protein misfolding and protein aggregation, I joined the Atherothrombosis and Vascular Biology lab to study the pro-inflammatory effects of misfolded proteins.

I am currently working on two projects. The first project deciphers the mechanistic insights into C-reactive protein (CRP) and misfolded protein interactions and examine which state of misfolded protein cause the structural modulation in CRP. The second project explores the role of CRP isoform in platelet activation, its potential binding receptor and downstream signalling. To address the knowledge gaps in abovementioned projects, I am using various cutting-edge in silico and in vitro technologies comprising protein-protein interaction modelling, cryo-electron microscopy, single particle analysis, cryo-electron tomography, surface plasmon resonance, isothermal titration calorimetry etc. Exploring the new pro-inflammatory pathways due to CRP will facilitate the designing novel drugs.