Skip to primary navigation Skip to main content
0 item $0.00

Computational Biology and Clinical Informatics

Understand human biology for better personalised medicines.

Read more

Laboratory head

Close
i Profile of author

Latest Achievements

Anders Young Investigator Award (2017)

Dr Álvaro Romanha Award (2017)

Jack Brockhoff Early Career Researcher Award (2016)

Dr Antoniana Ursine Krettli Award (2016)

Dr Naftale Katz Award (2015)

Read full biography
Associate Professor David Ascher
We are experts in developing extremely effective methods to analyse large amounts of biological data, greatly improving our understanding of human biology and personalised medicine

 

About the Computational Biology and Clinical Informatics laboratory

On-going technological advancements have led to dramatic increases in the amounts of biological data being generated. Along with the evolution of high performance computing and computational tools, this has provided us with a wealth of information, analytical power and the opportunity to investigate fundamental health and biotechnological problems of a different magnitude and kind, complementary to and able to guide conventional approaches. Our laboratory is interested in developing and experimentally validating novel computational methods to exploit this data, enhancing the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.

One of our main areas of interest is in the development of predictive and analytical tools and databases to investigate and understand the relationship between protein sequence, structure and function and phenotype, allowing us to gain unique insights into:

  • The molecular basis of genetic diseases, including cancer.
  • Understanding the molecular mechanisms behind drug resistance, to guide personalised patient treatment and the development of resistance resistant drugs.
  • Evolutionary insights derived from the analysis of protein structure and function.
  • Small molecule activity and toxicity as an aid to the design of novel drugs.

Our tools

We have developed and host a wide range of widely used and freely-available tools, including:

Arpeggio
Calculation and visualisation of all molecular interactions.

EasyVS
Reliable and open source virtual screening and clustering.

CSM-lig
Predicting the protein binding affinity of small molecules.

MTR Viewer
Quantification of the extent of localised purifying selection in protein-coding sequences.

mCSM-Stability
Predicting effects of mutations on protein stability.

DUET
An integrated method for predicting effects of mutations on protein stability.

DynaMut
Analysis and visualisation of protein dynamics using normal mode analysis. Quantitative prediction of the effects of missense mutations on protein dynamics and stability.

SDM2
An optimised knowledge based method for predicting effects of mutations on protein stability.

mCSM-PPI
Predicting effects of mutations on the affinity of protein-protein interactions.

mCSM-PPI2
Optimised predictions of the effects of mutations on the affinity of protein-protein interactions.

mCSM-AB
Predicting effects of mutations on antibody-antigen binding affinity.

mCSM-AB2
Optimised predictions of the effects of mutations on antibody-antigen binding affinity.

mCSM-DNA
Predicting effects of mutations on the affinity of protein-DNA interactions.

mCSM-NAv2
Optimised predictions of the effects of mutations on the affinity of protein-nucleic acid interactions.

mCSM-lig
Predicting effects of protein mutations on affinity for small molecules.

Kinact
Identification of protein kinase activating mutations.

pkCSM
Predicting small molecule pharmacokinetic and toxicity properties.

DendPoint
Prediction and optimisation of dendrimer intravenous pharmacokinetic profiles.

Platinum DB
Structural database of experimentally measured effects of missense mutations on protein-ligand complexes.

TROMBONE DB
Optimisation of Botulinum and Tetnus neurotoxins for medicinal purposes.

Symphony DB
Classification of VHL missense mutations according to risk of clear cell Renal carcinoma.

Support us

With the rising number of Australians affected by diabetes, heart disease and stroke, the need for research is more critical than ever.

Find out more