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Xiangdeng Lai

MSc, Sichuan University

I am a PhD student specialising in exercise physiology, cellular metabolism, and extracellular vesicle biology. I finished my Master’s degree in 2024 at Sichuan University in China. My master’s research focused on the regulatory role of lactate signalling pathways in skeletal muscle lipid metabolism and mitochondrial adaptation. I focused on the lactate receptor GPR81 and its downstream cAMP–PKA signalling pathway. I investigated how acute aerobic exercise and long-term endurance training influence muscle triglyceride storage, lipid breakdown and synthesis, as well as changes in mitochondrial content and function.

My research focuses on explaining how physical exercise promotes systemic health by regulating inter-tissue communication at the molecular level. I am especially interested in how extracellular vesicles (EVs) released during exercise function as signalling molecules that coordinate systemic metabolic responses.

My PhD studies will primarily address three key questions:

  1. What precisely is delivered in these EVs?
  2. How can we quantitate where these EVs go?
  3. What governs EV tropism in the organism?

The aim of this PhD project is to find the answers to these important questions. To do so, we will construct an entirely new in vivo exercise/EV protein atlas in mice, using recently pioneered techniques. The aim of this research is to find new ways to treat metabolic diseases and to learn more about how extracellular vesicles work in the body during exercise.

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