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Student research project

Supervisor(s): Morag Young and Kate Weeks

Project summary

Nuclear receptors associate with co-regulatory proteins in order to modulate gene transcription: These co-regulators can have profound effects on receptor activity and may be targeted therapeutically for the treatment of a range of diseases. We have identified novel mineralocorticoid receptor (MR) co-regulators from the heart and kidney and this project will determine whether they are expressed in a tissue and cell selective manner using RTPCR of archival tissues and immunostaining of heart and kidney cells.

Tissue culture approaches will be used to investigate how novel coregulators modify MR function in heart and kidney cells under normal conditions, in stressed cells and in response to different hormone ligands of the MR. This project may be combined with a second project offered in this laboratory investigating other transcriptional partners for steroid hormone receptors, the HDACs.

Related methods, skills or technologies

This project is suitable for a Masters, Honours or PhD student and will involve the application of various techniques including a suite of molecular biology techniques, cell culture, western blotting and RT.

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