Student research project
Supervisor(s): Professor Xiaowei Wang, Dr Mark Vidallon and Dr Aidan Walsh
Project summary
Research in the Molecular Imaging and Theranostics lab is focused on translational research that links the findings from basic science to the practical applications that enhance human health and well-being in clinical settings. We are particularly interested in developing innovative therapies using mRNA (messenger RNA) to treat or prevent cardiovascular diseases (CVDs). mRNA therapeutics have the potential to revolutionise the field of medicine by providing targeted treatments tailored to individual patients.
Cardiovascular disease is the leading cause of death globally, and atherosclerosis, a chronic inflammatory condition, is a primary contributor to most CVDs. Early detection, prevention, and even reversal of atherosclerosis can significantly reduce the occurrence of devastating events such as heart attacks.
The versatility of mRNA therapy enables us to load the nanoparticles with specific mRNA molecules that target the underlying causes of atherosclerosis. By identifying new mRNA targets associated with the disease, we can develop innovative therapeutic approaches. These mRNA molecules can instruct cells to produce proteins that counteract inflammation, promote tissue repair, or modulate the immune response. By delivering these tailored mRNA therapies directly to the affected areas, we can achieve more precise and effective treatments.
The significance of this project lies in the potential of mRNA therapeutics to revolutionise the field of cardiovascular medicine. By utilising targeted nanoparticles for diagnosis and treatment, we can detect atherosclerosis at an early stage and provide timely interventions, thereby preventing the development of further cardiovascular diseases. This approach has the added advantage of potentially reducing healthcare expenses in the long run, as early detection and treatment can save lives and mitigate the burden of costly interventions.
Related methods, skills or technologies
The project is suitable for a Masters or PhD student and will involve applying various skills and techniques including cell culture, flow cytometry, molecular biology, qPCR, mRNA design and production, microscopy, animal models and statistics.
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