Student research project
Supervisor(s): Professor Xiaowei Wang and Dr Mark Vidallon
This project is focused on the development of novel nanoparticles for controlled or trigger release of their therapeutic cargo.
Project summary
Research in the Molecular Imaging and Theranostics lab focuses on translational research that aims to connect the findings from basic science to practical applications that can improve human health in clinical settings. We are developing nanoparticles that respond to specific triggers and allow controlled release of drug and gene therapies at targeted locations in the body. This approach provides improved precision and efficacy while minimising side effects.
One of our main focuses is on cardiovascular disease (CVD), which is the leading cause of death globally. Atherosclerosis, a chronic inflammatory condition, underlies most CVDs. Early detection, prevention, and regression of atherosclerosis are crucial in preventing devastating events such as heart attacks.
To address this, we are creating nanoparticles that can respond to stimuli and release drugs or gene therapeutics in a controlled manner. These stimuli can be external factors like light or temperature, or internal factors like pH or enzymes present at the disease site. By designing nanoparticles that can sense these triggers, we can ensure that the therapies are released specifically at the affected areas, optimising their effectiveness while minimising off-target effects.
In our lab, we are specifically focusing on integrating these stimuli-responsive properties into nanoparticles. We are engineering these particles to respond to factors like inflammation markers or disease-specific environments in order to trigger the release of therapeutic payloads. By incorporating drug or gene therapies into these nanoparticles, we can precisely deliver them to the desired location and ensure their timely release for maximum therapeutic benefit.
The significance of this project lies in the potential for stimuli-responsive nanoparticles to revolutionise the treatment of cardiovascular diseases. By allowing controlled release of therapies at targeted sites, these nanoparticles offer enhanced precision and efficacy. Furthermore, they minimise the potential for side-effects by avoiding widespread distribution of the therapies throughout the body.
Related methods, skills or technologies
The project is suitable for an Honours, Masters or PhD student and will involve applying various skills and techniques including biomaterial selections, generation of nano-/micro-particles, cell cultures, flow cytometry, flow adhesion assays, microscopy, animal models and statistics.
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