Student research project
Supervisor(s): Professor David Greening
The Molecular Proteomics laboratory is focused on understanding the molecular function of extracellular vesicles (EVs) and how their intercellular signalling is important in normal physiology and pathologies; including cardiometabolic disease with the goal of identifying new deliverable therapeutic targets. We apply quantitative proteomics and various functional and molecular approaches to understand the composition, signalling, and function of EVs. The advanced approaches developed in our lab have identified novel regulators of cell function and EV biology, design of candidate drug delivery vehicles, and functional delivery of proteins. Our team has utilised this knowledge for commercial and translational potential.
Project summary
Circulating nano-sized extracellular vesicles (EVs) hold tremendous potential to diagnose and treat CVDs. EVs carry specific information and are responsible for efficient intercellular communication that is important in many physiological processes and their content perturbed in the progression of several diseases, including CVD. Coronary artery disease (CAD) is the leading cause of death worldwide.
This project will develop our unique strategies to define circulating EVs, their proteome and phosphoproteome landscape, and their utility as biomarkers in the context of CAD progression. Moreover, biological functions of specific molecular targets in EVs will be investigated to further our understanding of the progression of CAD.
This project is suitable for a PhD student and will expose you to numerous skills and technologies, including molecular biology and proteomics.
Browse all postgraduate research opportunities