Despite small membranous extracellular vesicles (EVs) representing a significant mechanism for intracellular communication, little is known about EV-mediated regulation of cells within the healthy and diseased heart. Heart disease remains a major health problem all around the world. Because the current interventions show only limited ability to repair the damaged heart, advances in mechanistic understanding and treatment of cardiac injury would have major clinical significance.
This project focuses on integrating mass spectrometry-based proteomics, phosphoproteomics, lipidomics, and informatics to understand how extracellular vesicles regulate cardiac cells and their regeneration following injury. This information will provide to establish new clinically effective therapeutics