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Preclinical Cardiology MicrosurgeryThe Preclinical Cardiology Microsurgery and Imaging Platform (PCMIP) is a small and specialised group of microsurgery and imaging scientists at the Baker Institute. The platform was developed and introduced in 2002 with the aim of leveraging the combined expertise of cardiologists, researchers and preclinical microsurgeons. The PCMIP continues to develop techniques at the leading edge of preclinical cardiology research.

Since 2002, the PCMIP has collaborated on countless high-impact preclinical projects and publications by Baker Institute researchers and has completed as many as 15 externally contracted preclinical projects and trials.

The PCMIP is a preferred microsurgery partner of AD Instruments and provides highly specialised training in preclinical surgical and imaging techniques to scientists from all around the country and abroad. Register for upcoming events.

If you would like more information about the services or study capabilities of the PCMIP, please contact Dr Daniel Donner.

Preclinical trials and support

Contact us for studies requiring small models, single cardiac assessments through to complete preclinical trial management.

Honours, Masters and PhD students

Contact us for co-/supervision in research projects that help develop new microsurgery and imaging techniques for leading edge cardiology research.

Preclinical capabilities

Microsurgery models

  • Myocardial infarction: cardioprotection and cardiac rupture studies.
  • Ischemia-Reperfusion: cardioprotection and chronic heart failure studies.
  • Aortic banding/constriction: hypertension, hypertrophy and chronic heart failure studies.

Microsurgical assessments

  • Pressure catheterisation: intracardiac and arterial pressure studies.
  • Pressure-volume catheterisation: intracardiac pressure-volume loop studies.
  • Electrophysiology: surface lead, implantable telemetry and EP catheter studies.

Cardiac imaging

  • Structural echocardiography: 1-D and 2-D geometry assessments.
  • Functional echocardiography: systolic and diastolic (Doppler) assessments.
  • Cardiac mechanics: stress-strain and segmental dyssynchony assessments.

Video: Images acquired with the Alfred Research Alliance Preclinical Imaging Facility's new state-of-the-art 9.4T MRI showing the four chambers of a normal mouse heart and a failing heart as it beats. Images were collected as part of a new collaboration investigating heart disease headed by A/Prof Julie McMullen from the Cardiac Hypertrophy laboratory at the Baker Heart and Diabetes Institute. The images were acquired by Dr David Wright, Head of Preclinical Imaging in the Department of Neuroscience, Central Clinical School, and Dr Daniel Donner from the Preclinical Cardiology Microsurgery and Imaging Platform at the Baker Institute. (13sec)

Leadership

Professor Julie McMullen
Domain Head, and Preclinical Cardiology Microsurgery and Imaging Platform Manager

Dr Daniel Donner
Preclinical Microsurgery, Training and Contract Management

Dr Helen Kiriazis
Preclinical Imaging and Training

Support us

With the rising number of Australians affected by diabetes, heart disease and stroke, the need for research is more critical than ever.

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