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Student research project

Supervisors: Professor Peter Meikle, Dr Kevin Huynh

Research focus

The Metabolomics Laboratory uses state-of-the-art tandem mass spectrometry to obtain metabolic/lipid profiles from cell and animal models in addition to clinically relevant human samples to develop new approaches to diagnosis, risk assessment and therapy for diabetes and cardiovascular disease.

Project summary

This study aims to generate a novel approach in comprehensive lipidomic profiling using high resolution mass spectrometry approaches in conjunction with computational biology.

Key points:

  1. Lipids are key biological molecules essential to life. Lipidomics is the characterisation and study of the complete lipidome of a biological system (fluid, cell, tissue, organism). In humans, plasma is an easy to obtain bio-fluid where lipids have been demonstrated to be perturbed in various disease settings.
  2. Diseases can affect everyone differently, in order to better understand the relationship between lipids and disease, larger population studies are needed. Clinically related studies in the field have been limited, owing to the limitations in the rate where plasma samples can be profiled in a comprehensive manner.

This project is suitable for a PhD student who should be technology/computation oriented.

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