Ms Qi Hui Poh
Qi Hui graduated from the Bachelor of Biomedical Science with First Class Honours at the La Trobe Institute for Molecular Science in 2018. During her Honours year, she took on a multi-disciplinary approach in conjunction with the Hudson Institute of Medical Research in applying a novel human embryo mimetic to gain crucial insights into human implantation — a significant problem which accounts for ~75% of unsuccessful pregnancies. This involved three-dimensional culture of specialised cell spheroids using human trophectoderm stem cells, which comprises the outer layer of an appropriately developed embryo, thus forming the interface of embryo-endometrium communication during implantation. Importantly, she applied this model to focus on the proteomic profiling of embryo-derived extracellular vesicles (EVs). For this project, she applied a range of biochemistry/molecular biology techniques, including three-dimensional cell culture and EV isolation and characterisation, paired with high-resolution and high-accuracy mass spectrometry.
As of 2019, Qi Hui continues on with the Molecular Proteomics laboratory as a PhD student under the Joint Baker Heart and Diabetes Institute - La Trobe Postgraduate Research Scholarship (LTURPS). With an interest in expanding her experience in EV and proteomic techniques, she is keen to apply quantitative omics and systems biology to investigate cellular biology and signalling in various physiological and pathological processes, thus identifying the molecular drivers of disease progression. Currently, she aims to expand on the lab’s collaborative network at Baker in investigating the molecular networks of the human cardiac cellulome and the underlying metabolic reprogramming of these networks in the context of heart failure.